AMRI Chemist/Research Scientist I/II/III in Indianapolis, Indiana

*Chemist/Research Scientist I/II/III *

Location: Indianapolis, IN


Albany Molecular Research Inc. provides global contract research and manufacturing services to the pharmaceutical and biotechnology industries

RESPONSIBILITIES


  • Development and optimization of synthetic routes for preparation of final compounds and intermediates demonstrated in mg’s to 250 g scale and suitably for their potential scale-up to 500 g-2 kg by external partners (through tech-transfer of the developed methods).

  • Synthesis of key intermediates in 20-500 g scale.

  • Synthesis and rapid delivery of key final compounds in 5-500 g scale with the required purity and with very tight timelines.

  • Set-up/build/maintain appropriate experimental equipment to accomplish project goals, including pressure equipment such as autoclaves, flow chemistry equipment, typical laboratory glassware, etc.

  • Rapidly identification of optimal reaction conditions via parallel screening or use of flow equipment.

  • Regular evaluation of chemical safety and hazards of synthetic transformations that eventually may be scaled-up.

  • Work with several computer systems to collect and maintain data – e.g. eLN, analytical data, Microsoft office (Word, Excel, Powerpoint), safety evaluations

  • Maintain chemical stock including solvents, gases, chemicals and catalysts. Assist in lab upkeep including: clean lab and lab reactors, used catalyst pick up, waste drum disposal, etc.

  • Accurately communicate results via eLN, reports and presentations.

  • Take appropriate steps to protect Lilly’s intellectual property.








MINIMUM REQUIREMENTS

  • Degree in Chemistry, preferably with demonstrated experience in organic synthesis and synthetic methodology, either in pharmaceutical or chemical industry.

  • Ability to execute a variety of organic reactions and working knowledge of synthetic chemistry optimization, reaction parameters control, work-up, and purification methods of multi-gram preparation of organic compounds.

  • Working knowledge of modern synthetic chemistry methodologies, experimental work, analytical techniques, isolation, purification techniques and structural analysis of synthetic organic molecules.

  • General knowledge of reaction mechanisms & thermodynamics and experience in the assessment of chemical safety and hazards of synthetic transformations.

  • Ability to maintain current literature awareness of chemical transformations.

  • Attention to detail and ability to record observations accurately.

  • Mechanical aptitude – ability to take apart and (re)build lab equipment such as pressure reactors/systems and flow chemistry equipment.

  • Ability to efficiently search the chemical literature; familiarity with SciFinder and/or Reaxys

PREFERABLE ATTRIBUTES

  • Previous experience running pressure reactions and/or flow systems.

  • Knowledge of pressure fittings.

  • Ability to prioritize work appropriately to progress multiple projects simultaneously under flexible project goals.

Job: *Drug Discovery

Organization: *AMRI Albany

Title: Chemist/Research Scientist I/II/III

Location: IN-Indianapolis

Requisition ID: 1000839